Behçet病患者の赤血球C3b receptor活性について

Erythrocyte C3b receptor in Behçet disease

　Behçet病患者87名を対象として，赤血球C3b receptor活性を免疫粘着凝集反応を用いて測定し，以下の結果を得た．

（1） Behget病患者87名中28名（32.3％）に赤血球C3b receptorの活性低下を認めた．これは健常成人29名中2名（6.8％）にくらべて有意（p＜0.01）の低下であった．

（2） C3b receptor活性の低下は，眼底型より前眼部型患者に出現率が高かった（p＜0.001）．

（3）眼外症状の活動性は，陽性例にくらべて低下例で高く（p＜0.05），白血球数，血沈値も高値を示し，CRP陽性率には有意の増加がみられた（p＜0.01）．

（4）赤血球C3b receptorは，Behçet病の発症，経過，予後に重要な役割を果たしていると思われた．

We determined the activity of C3b receptor on the erythrocytes in 87 cases of Behçet disease. Immune-adherence hemagglutination method was used.

The activity of C3b receptor was reduced in 28 cases (32%) of the series. As a significant contrast, it was reduced in only 2 (7%) out of 29 healthy adults (p< 0.01).

The incidence of reduced C3b receptor activity was greater in the anterior ocular type than in the fundus type of the disease (p<0.001) .

Patients with defective C3b activity tended to show higher scores for extraocular involvement of the disease than in those with positive C3b activity (p<0.05). A similar tendency was present-for the former group to show higher peripheral leukocyte counts, erythrocyte sedimentation rate, and elevated CRP values(p<0.01). These findings seemed to indicate that the C3b recep-tor on the erythrocytes were closely associated in the onset, clinical course and prognosis of Behcet disease.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(5) : 473-476, 1986