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T lymphocyte subsets in Behset's disease Mitsuko Kogure 1 , Keiji Yoshikawa 1 , Yoshinori Takahashi 1 , Kyoko Sakai 1 1Dep. of Ophthalmol., Tokyo Women's Med. Coll. pp.121-126
Published Date 1985/2/15
DOI https://doi.org/10.11477/mf.1410209325
  • Abstract
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We evaluated the peripheral T cell subsets in 75 patients with Behçet's disease using OKT series hybridoma monoclonal antibodies.

The percentages of OKT3+ and OKT4+ cells were significantly increased and OKTa1+significant-ly decreased in patients with Behçet's disease as compared with healthy controls.

OKT3+ cells increased significantly during the attacks. OKT8+ cells increased during ocular at-tacks and OKT4+ cells during extraocular attacks.

The ratio OKT4+/OKT8+ tended to increaseduring the period when the extraocular attacks occurred frequently. It tended to decrease during the period of ocular attacks.

OKT8+ cells increased towards the late stage of ocular attacks and after, as if they had contributed to the repair of the attacks. A decrease of OKT4+ cells seemed to play some role in the onset ofocular attacks.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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