Behçet病患者の末梢血Tリンパ球サブセットの動態

T lymphocyte subsets in Behset's disease

　Behçet病患者75例を対象に，モノクロナル抗体を用いて臨床経過に伴うリンパ球subsetの動態を観察し，眼発症時および発症後の再燃，寛解のくり返しに細胞性免疫も深くかかわっていることが示唆された．

（1）本症患者のOKT 3^＋，　OKT 4^＋の増加，OKIa₁^＋の低下は，健常対照にくらべて有意であった．

（2）発作期のOKT 3^＋の増加は，健常対照に対して有意で，眼発作期にはOKT 8^＋の，眼外発作期にはOKT 4^＋の増加が明らかにみられ，OKT 4^＋／OKT 8^＋比の増加は眼外症状の，低下は眼症状の多発時にみられる傾向があった．

（3）眼発作期におけるOKT 8^＋の増加は，眼発作の修復に関与するかのごとく，極期をすぎた発作後期から発作後にかけてみられ，一方，眼発症時にはOKT 4^＋の減少が何らかの形で関与していると思われた．

We evaluated the peripheral T cell subsets in 75 patients with Behçet's disease using OKT series hybridoma monoclonal antibodies.

The percentages of OKT3⁺ and OKT4⁺ cells were significantly increased and OKTa₁⁺significant-ly decreased in patients with Behçet's disease as compared with healthy controls.

OKT3⁺ cells increased significantly during the attacks. OKT8⁺ cells increased during ocular at-tacks and OKT4⁺ cells during extraocular attacks.

The ratio OKT4⁺/OKT8⁺ tended to increaseduring the period when the extraocular attacks occurred frequently. It tended to decrease during the period of ocular attacks.

OKT8⁺ cells increased towards the late stage of ocular attacks and after, as if they had contributed to the repair of the attacks. A decrease of OKT4⁺ cells seemed to play some role in the onset ofocular attacks.