Behçet病におけるInterleukin−2レセプター陽性細胞（IL−2R＋）の解析

Interleukin-2 receptor bearing cells in Behçet's disease

　二重螢光染色の手技を用いて，Behçet病患者105例の末梢血活性化Tリンパ球の種類およびTリンパ球の機能亜群を分析した。

　対照にくらべてBehçet病では，活性化されたT細胞およびB細胞がともに有意に増加していた。活性化T細胞の中では，対照にくらべて活性化Leu2a細胞（細胞障害性／サプレッサーT）に有意の増加がみられた。

　サプレッサーT細胞は眼発作開始直後に増加し，発作中は高値を維持し，眼発作直前にくらべ有意の差を認めた。

　ヘルパーT細胞は眼発作直前から発作開始時にかけて高い傾向がみられた。

　シクロスポリン内服例のサプレッサーT細胞は，非内服例にくらべて高値であった。

We evaluated 105 petients with Behçet's disease concerning the activated lymphocyte subpopula-tions and functional T lymphocyte assay in the peripheral blood. We used double color flow cytometry technique.

The patients showed significantly more active T and B (IL-2R^*) cells than in volunteer controls. The increased T lymphocytes positively correlated with increased levels of activated Leu2a (cytotox-ic/suppressor T) lymphocytes. IL-2R⁺. Leu2a⁺ lymphocytes was significantly increased in patients than in controls (p<0.01).

The number of circulating suppressor T cells was elevated after onset of ocular attacks to remain at high levels throughout the period of attack when compared with the value just before the attacks (p< 0.025). The helper T cells showed temporary increase immediately before till immediately after onset of attacks.

Patients treated with systemic cyclosporin showed increased levels of suppressor T cells when compared with those without.