Behçet病におけるinterleukin 2 system

Interleukin 2 in the peripheral blood in Behçet disease

　Behçet病の免疫応答における細胞間調節機構を明らかにする目的で，患者97例（235検体）のinterleukin （IL）-2 receptor陽性（R^＋）細胞，IL-2産生能を測定し，本症の病態形成にIL-2系の関与することを示唆した．

　1．IL-2R^＋細胞は健常対照にくらべて高値（P＜0.001）であったが，IL-2産生能には有意の差がなかった．

　2．本症の活動期におけるIL-2産生能は，非活動期にくらべて有意に高値であったが，IL同2R^＋細胞の値には有意の差がなく，恒常的に高値を示した．

　3．IL-2産生能は眼活動性，眼外活動性がともに高い群で高値（P＜0.01）を示した．

　4．IL-2R^＋細胞，IL-2産生能の値は，ともに眼発作前後に大きく変動した．

　5．Ciclosporin内服前後の両測定値に大きな変動はなかった．

　6．IL-2R^{細胞とIL-2産生能との間に有意の相関はなかった．}

We evaluated the role of interleukin-2 system in regulating immune responses in Behçet disease. We determined the expression of interleukin-2 receptor (IL-2) and the capacity of production of interleukin -2 (IL-2P) in 235 peripheral blood samples from 97 patients of the disease.

While the IL-2P values failed to show significant differences when compared to control, IL-2R was significantly higher in the patients than in control (p<0.001). The IL-2P levels were significantlyelevated during exacerbation of the disease as compared to remission (p<0.01). The IL-2R values remained at sustained high levels without signifi-cant fluctuation. The IL-2P values were elevated in cases with active ocular and extraocular manifesta-tions of the disease (p<0.01). Both IL-2R and IL-2P values showed abrupt changes before and after ocular attacks of the disease. Systemic cyclosporin did not influence the IL-2R or IL-2P values. There was no correlation between IL-2R and IL-2P val-ues.

Rinsho Ganka (Jpn J Clin Ophthalmol) 41(8) : 921-925, 1987