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Japanese

OPTIC GLIOMA WITH ABOUNDANT ROSENTHAL FIBERS ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE: A CASE REPORT Hidenobu Aoki 1 , Motohide Ogashiwa 1 , Yoshikazu Saito 1 , Kiyoshi Wakutani 2 1Division of Neurosurgery and Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine pp.1313-1318
Published Date 1970/11/1
DOI https://doi.org/10.11477/mf.1406202814
  • Abstract
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Optic glioma associated with von Recklinghau-sen's disease has been rarely reported in Japan.

A 13-year-old girl was admitted to our clinic, because of visual disturbance on four years duration. Café-au-lait spots and subcutaneous nodules had been noticed since her childhood.

The findings on physical examinations were nor-mal except for bitemporal hemianopia and atrophy of the optic discs. Carotid angiography and pneumoencephalography revealed the presence of a space-occupying lesion in the suprasellar region.

By the right fronto-temporal craniotomy, a large fleshy tumor was observed in the chiasmal region, extending posteriorly to the interpeduncular fossa, and involved both optic nerves and optic chiasm. Subtotal removal of the tumor including the right optic nerve was followed by radiation therapy of 60Co.

Microscopically, the tumor composed of spongio-blasts and astrocytes admixed with abundant eosino-philic globules and rods. On histochemical exami-nations, these bodies were corresponded to so-called "Rosenthal fibers". The origin and nature of this fiber were discussed.

Review of 63 gliomas of the optic nerve and chiasm in Japanese literatures disclosed 3 cases (4.7%) associating with von Recklinghausea's dis-ease. Of 70 autopsy cases of von Recklinghausen's disease between 1958 and 1967 in our country, only one case (1.4%) was associated with glioma of the optic nerve and chiasm.


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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