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Brain and Nerve No to Shinkei Volume 25, Issue 5 （May 1973）

Brain and Nerve 脳と神経 25巻5号（1973年5月発行）

Japanese English

症例報告

脳底部線維軟骨腫の1剖検例 FIBROCHONDROMA OF THE BASE OF THE BRAIN: REPORT OF AN AUTOPSIED CASE 青木秀暢 ¹ , 小柏元英 ² , 喜種善典 ² , 中村征郎 ² , 高橋和郎 ³ , 神田道郎 ⁴ Hidenobu Aoki ¹ , Motohide Ogashiwa ² , Yoshinori Kidane ² , Seiro Nakamura ² , Kazuro Takahashi ³ , Michiro Kanda ⁴ ¹松江市立病院脳神経外科 ²鳥取大学医学部脳幹研脳神経外科 ³鳥取大学医学部脳神経病理 ⁴鳥取大学医学部第二病理 ¹Department of Neurosurgery, Matsue Municipal Hospital ²Division of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine ³Neuropathology, Tottori University School of Medicine ⁴Department of Pathology, Tottori University School of Medicine pp.595-600

発行日 1973年5月1日 Published Date 1973/5/1

DOI https://doi.org/10.11477/mf.1406203319

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Abstract 文献概要
1ページ目 Look Inside

はじめに

　頭蓋および頭蓋内に発生するchondromaはまれな腫瘍である。諸家の報告^{5）15）21）}でも全脳腫瘍に対する割合は0.1〜0.35％であり，本邦においては斉藤ら^15）の4例をはじめ，現在まで11例^{3）4）11）16）17）18）19）}をみるにすぎない。しかも発生部位からみると，頭蓋および頭蓋底骨軟骨結合部よりの発生がそのほとんどで，脳内からの発生は所^19），　Raskindら^13），Wuら^20）など数例をみるのみである。

　われわれは脳底部（視床下部下面を中心とした）のfibrochondromaの1例を経験し，手術後約9カ月目に剖検する機会を得たので，本腫瘍の発生について文献的考察を加え報告する。

1) Intracranial and calvarial chondromas have been rarely reported. They usually have appeared to arise from the synchondrosis of the base of the skull.

A 24 year-old male was admitted to our clinic on June 24, 1970, because of disturbance of cons-ciousness. Physical examinations were as followed ; dehydration, semicomatose state, left hemiparesis with pathologic relexes, anisocoria (rt<lt), absent of left light reflex without chocked disc. The find-ings on endocrinological examinations revealed general dysfunction of diencephalo-hypophyseal system, adrenal and sexual glands.

Plain craniogram showed definite calcification inthe suprasellar region (2.5 × 2.0cm in size) with-out destruction of the anterior and posterior clinoid processes and clivus. Carotid and vertebral angio-graphies revealed a space-occupying lesion in the supra-and parasellar regions from the base of the skull.

A bifrontal craniotomy was performed on July 6, 1970. A hard nodular tumor was observed in the chiasmal region, extending posteriorly to the interpeduncular fossa. Partial removal of the tumor was followed by radiotherapy of ⁶⁰Co.

2) At autopsy, a large tumor (5 × 4 × 5cm in size) was found in the base of the brain without involv-ing the dura and synchondrosis of the base of theskull. It was bony in consistencty and well de-marcated with circumscribed parts of brownish appearance. The bony portion of the tumor showed histologically feature of benign chondroma with myxoid degeneration in a part and the circums-cribed portions contained fibroma.

3) Cartilaginous tumors arising from the intra-cranial structures are of rare occurrence. It appears that our case originates from residual nests of embryonic cartilaginous tissue of the base of the brain. The origin and nature of this tumor were discussed.