精神科領域におけるChlorpromazineの臨床経験

Clinical Experience of Chlorpromazine in Psychiatric Therapy

I．緒言

　周知の如く1950年にフランスで合成されたChlorpromazine （以下C．P．と略す）は．1951年H．Laborit等及びP．Hugenardによつて，人工冬眠剤として臨床的に使用されたが，精神科領域に於いても，1952年Hamon等，Delay等及びDechamps等によって応用されて以来，欧米各国，更に我国に於いても，これに関する研究追試が盛に行われて来た。私も昭和30年3月から10月迄，8カ月間に36例の精神疾患の患者に使用したので，猶症例も少く，作用機序，遠隔成績，其他詳細に検討さるべき問題を残したまま乍ら，一応これまでに得られた結果を報告したいと思う。

This report is based upon our experience in the use of chlorpromazine at the Hukuyama Jinpuso Hospital (lunatic asylum).

Our clinical material is 36 psychotic patients, including 24 schizophrenia.

C.P.was given orally 200-400mg a day.

At schizophrenia, C.P. was more effective for acute, new cases and catatonia, 40% of the cases, for which E.C.T. and I.C. T.are not effective, was improved by C.P.

In our cases, manic state and delirium tre-mens were improved,10 cases of 24 schizophre-nic patients, 3 cases of 5 neurotic patients ware much improved, dementia senilis and psycho-pathia were unchanged, but a number of patie-nts became cooperative to nursing care.

In the psychic symptoms, insomnia, emot-ional irritability and instability, stupor, hallu-zination, delusion and inaccessibleness were most disappeared by C.P.

Observing our all cases, we had the impres-sion that long duration of small doses was pointless, so far as the side effects of C.P.were not so harmful, the largest doses was most effective.