陳旧分裂病に対するChlorpromazineの使用経験

Experience in Use of Chlorpromazine in Chronic Schizophrenia

　「精神病に対する化学療法」或いは「薬物的ロボトミー」等と称せられるChlorpromazineの精神科領域における応用は我国でも最近いよいよ盛になつてきた。殊に精神運動興奮，或いは情動緊張の著しい例に用いて相当の成果を挙げている。また新鮮且活溌な病像に対する治療効果の検討も既に多数試みられている。しかし人格荒廃の著しい分裂病，殊に動きに乏しい陳旧例に本剤が如何なる影響を及ぼすか，この観察を試みた者の数は少ない。

　私が治療の対象とした分裂病者たちは，10年患者といわれる，陳旧にして荒廃した症例であるが特に，1）自発性，2）接触性の2点において重篤な人格欠陥を示すもののみが選ばれた。本報告において私は，この二つの人格欠陥に対するChlor—promazineの効果を考察してみようと思う。Chlorpromazineとしては吉富製薬から提供を受けた同社製のContominを用いた。

I have examined the effect of"Chlorproma-zine"in those seven cases of chronic schizoph-renia which showed especially noticable defects of personal character in regard to spontaneity and relationship.

After the treatment chiefly by oral administ-ration, extending over a period of thirty eight to forty three days, the result is that in all ca-ses relationship recovered first at once, and besides in five of them spontaneity also regai-ned. But to my regret, nearly most of those cases showed sign of falling back again into a former state either during the treatment or imm-ediately after the completion of it.

Therfore, I can say that this medicine has no effect worth mentioning on chronic schizo-phrenia, but of course it must be admitted that even after their relapse, various training be-came somewhat easier than before the treat-ment, and so far as this fact is concerned, I cannot help admitting the continous effect of this medieine, though it is slight.