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Prognosis of Duchenne Muscular Dystrophy with Mechanical Ventilation:Periodic hypoxemia during sleep Katsunori Tatara 1 , Takahiko Saijo 1 , Suguru Matsuoka 2 , Yasuhiro Kuroda 2 1Department of Pediatrics, National Sanatorium Tokushima Hospital 2Department of Pediatrics, Tokushima University School of Medicine Keyword: Duchenne型筋ジストロフィー , 人工呼吸法 , 睡眠時低酸素血症 , Duchenne muscular dystrophy , mechanical ventilation , periodic hypoxemia during sleep pp.281-285
Published Date 1997/3/15
DOI https://doi.org/10.11477/mf.1404901440
  • Abstract
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Overnight monitoring using a pulse oximeter was performed on 23 Duchenne muscular dystrotphy patients maintained on mechanical ventilation. The patients were comprised of 8 with chest respirator (CR), 8 with nasal intermittent positive pressure ventilation (NIPPV) and 7 with intermittent positive pressure ventilation through a tracheostomy (TIPPV). Seven age-matched volunteers underwent the same monitoring as controls. In the CR and NIPPV groups, there were some patients who demonstrated periodic O2 desaturation during sleep, whereas there were no such patients in the TIPPV and control groups. The proportions of the period of O2 desaturation (95%≧) during sleep were 44.6% in the CR group, 43.0% in the NIPPV, 15.3% in the TIPPV and 1.9% in the controls. There were statistically significant differences between the CR and NIPPV groups and the controls (p<0.05). Four patients belonging to the TIPPV group died during the observation period. All belonged to the TIPPV group and two of them died suddenly due to tracheal bleeding. Therefore regular respiratory func-tion tests, especially sleep monitoring by pulse oximetry, must be continued for patients maintained with NIPPV or CR.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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