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Effect of Roxithromycin on Endotoxin-induced Hypersecretion of Airway Goblet Cells Junko Nakata 1 , Jun Tamaoki 1 , Kiyoshi Takeyama 1 , Mitsuko Kondo 1 , Isao Yamawaki 1 , Kimio Konno 1 1First Department of Medicine, Tokyo Women's Medical College Keyword: マクロライド , 杯細胞 , 気道分泌 , macrolide , goblet cell , airway secretion pp.1089-1092
Published Date 1996/10/15
DOI https://doi.org/10.11477/mf.1404901353
  • Abstract
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Increased mucus glycoprotein secretion from airway goblet cells may play a significant role in the develop-ment of chronic airway infections such as diffuse pan-bronchiolitis and chronic bronchitis. To study the effect of macrolide on airway goblet cell secretion, we asses-sed the mucus score of guinea pig trachea, which is inversely related to the magnitude of mucus discharge. Inhaled LPS (5mg/kg) decreased mucus score and in-creased the number of neutrophils in bronchoalveolar lavage fluid. Oral administration of roxithromycin (0.5 -10mg/kg/day) for 7 days dose-dependently inhibited LPS-induced decrease in mucus score, with the maxi-mal inhibition being 48.7±9.3 % (p < 0.01). This effect was accompanied by the inhibition of neutrophil accu-mulation into bronchoalveolar lavage fluid. On the other hand, amoxicillin and cefaclor had no effect on goblet cell secretion and recruitment of neutrophils. These results suggest that macrolide probably decreases goblet cell hypersecretion by inhibiting neutrophil accumulation in the airway.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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