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Japanese

Effect of Histamine on Electrical Properties of Airway Epithelium and its Antagonism by Azelastine Jun Tamaoki 1 , Noritaka Sakai 1 , Kazuo Isono 1 , Toshinori Kanemura 1 , Kiyoshi Takeyarna 1 , Satomi Takeuchi 1 , Atsushi Chiyotani 1 , Takao Takizawa 1 1The First Department of Medicine, Tokyo Women's Medical College Keyword: 気道上皮細胞(airway epithelium) , イオントランスポート(ion transport) , 抗アレルギー薬(anti-allergic drug) pp.181-184
Published Date 1991/2/15
DOI https://doi.org/10.11477/mf.1404900228
  • Abstract
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To elucidate the mechanism of the action of his-tamine on bioelectric properties of the airway epith-elium and the fact that the anti-allingic agent azelas-tine is possibly antagonistic to it, we studied canine cultured tracheal epithelium under short-circuit condi-tions in vitro. Addition of histamine to the submucosal but not mucosal bath of Ussing chamber increased short-circuit current (Isc) in a dose-dependent fashion, the maximal increase and the EC50 value being 5.7±0.9 μA/cm2 (mean±SE, p<0.001) and 3×10-6M, respec-tively.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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