Effect of Roxithromycin on Ciliary Motility of Rabbit Tracheal Epithelium in Culture Jun Tamaoki 1 , Kiyoshi Takeyama 1 , Atsushi Chiyotani 1 , Noritaka Sakai 1 , Fumiko Yamauchi 1 , Takao Takizawa 1 1The First Department of Medicine, Tokyo Women's Medical College Keyword: ロキシスロマイシン(Roxithromycin) , マクロライド(macloride) , 粘液線毛輸送(mucociliary transport) pp.481-485
Published Date 1991/5/15
DOI https://doi.org/10.11477/mf.1404900279
  • Abstract
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Mucociliary transport plays an important role in the lung defense mechanism by clearing inhaled particles and bacteria from the respiratory tract. In the present study, we tried to determine whether roxithromycin (RXM), a new semisynthetic macrolide, can affect airway mucociliary functions and, if so, what the mecha-nism of its action is. To do so we measured ciliary beat frequency (CBF) of rabbit cultured tracheal epithelium by a photoelectric method. Addition of RXM (10-4M) to a Rose chamber containing epithelial cells caused a rapid increase in CBF from 12.1±0.6 to 16.2±0.8 Hz (mean±SE, p<0.001) within 5 min.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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