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Effect of calcium antagonist (etafenone hydrochloride) on the isolated guinea pig tracheal tissues Yoko Ishihara 1 , Hideki Yotsumoto 1 , Shoji Kudoh 1 , Kenji Sasaki 1 , Satoshi Kitamura 1 1Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo pp.767-771
Published Date 1978/8/15
DOI https://doi.org/10.11477/mf.1404203234
  • Abstract
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Etafenone hydrochloride, a calcium antagonist, is known to increase coronary arterial blood flow without cardiac stimulating effect.

Male guinea pigs, weighing 250-300g, were killed. Tracheal tissues, were suspended in a bioassay glass chamber superfused with Krebs-Henseleit solution at 37℃ saturated with oxygen and carbon dioxide (95 : 5, v/v).

Contraction and relaxation of these tissues were detected by an isotonic transducer and recorded using a polyrecorder.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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