Neo-Synephrin hydrochloride（Neo-Synesin KOWA）の耳鼻咽喉科領域への応用

　緒言

　最近の米国の耳鼻咽喉科領域の雑誌を読んでいると，よくNeo-synephrin或いはNeo-synephrinhydrochlorideと言う新藥が目につく。Neosynephrin hydrochlorideとは本来血管收縮剤及血圧上昇剤であるのに，何故鼻疾患に応用されるかに疑問を持ち種々文献を調査した処，既在の血管收縮剤に優る作用を有すると共に，鼻疾患治療藥としても抗生物質等の治療藥とは異なる作用及治療効果を有するのを知り，早速当教室に於ても其の追試を試みた。

　Neo-synephrin hydrochlorideは1934年頃American Medical Associationの藥学と化学に関する会議で認められ，米国N. N. R. の中に記載され，次いで米国藥局方の中に記載された。然し，此の藥剤の化学及生物学的特性に就いては，本邦にてはあまり知られていないので，先づ第一に此の藥剤の化学と他の既存の血管收縮剤に対する関係並びに其の藥理的作用について，簡単に文献的考察を進め，併せて臨床報告をしたいと思う。

　DAITO and HIRANO State that, clinically, there are manifold uses to which Neo-Synephrine Hydrochloride (Neo-Synesin Kowa) may be applied. It is an agent whose properties parallel with those of both, ephedrine and epinephrine hydrochlorides insofar as its parasympathomimetic action is concerned yet, more stable and less toxic when compared with the latter. As a therapeutic adjunct Neo-Synephrine Hydrochloride has shown favorable results by use in rhinitis of children and infants, chronic nasopharyngitis, common colds, both,in the acute and the chronic low grade sinusitis and for local instillations followsinus operations. Its use is without fear of side effects or of addictions ; because of its property inducing vasoconstriction markedly well the drug may be used in conjunction with other agents employed for local anesthesia specifically, to replace epinephrine hydrochloride which is, now, commonly used but, not altogether without toxicity. The authors are in expectancy to see further reports by other workers on this subject.