慢性化膿性中耳炎に対する局所的化学療法

　緒言

　急性化膿性中耳炎は，その起炎菌が大多数に於てペニシリン及びスルファミン剤に感受性の強いものであるから最近では之等患者は急速に治癒に向い，多くのものは1〜2週間にて治癒するものである．

　併し慢性化膿性中耳炎となると，その起炎菌，耳管炎，急性中耳炎の反復，体質解剖学的関係，環境等に多くの要因があり，古来治癒の困難な疾患とされ，多くの療法が研究発表されているが，決定的なものは之を認めない．

MITSUYOSHI used, in treatment of chronic ot-itis media after the causative bacteria having been dete mrned, a iocal applcation of streptomycin in solution and/or thiazine (sulfa-isoxy-thazol) in p-owder form. Results differed with cases depending upon the causative bacteria but in greater majori-ty of them the outcome was highly satisfactory. when the infective agent was due to presence of degenerative type of bacteria or streptococcus v-iridans the use of thiazine alone proved effective and,solikewise, was streptomycin towards some g-ram negative bacteria. However, when these two therapeutic agents were combined in their use the results were even better.