大脳半球摘除長期生存犬の観察

LONG TERM OBSERVATION ON HEMISPHERECTOMIZED DOGS

I．はしがき

　大脳半球摘除術の生体に及ぼす影響について，その病態生理を追求するため実験的研究による報告は，本邦では，中田，植木一門の報告^1）〜4）をはじめ，2,3の報告^5）をみるにすぎず，しかも長期生存犬について一貫した経過報告を行なつているものは，飯塚^2），渡辺^3），木之下^5）らの報告をみるにすぎない。著者らも大脳半球摘除に関する一連の研究^5）〜8）を行なつてきたが，ここに長期生存しえた3頭の実験犬について，術当初より剖検にいたるまでの約1年間の観察を報告し，いささか考察を加えご参考に供したい。

The results obtained by long term observation for 9 months or 1 year on the three hemispherecto-mized dogs reserving only thalamus and hypothala-mus were reported.

These results were as followes.

1) Motoric hemiplegia and forced cycle movement were restored to almost normal at 1 year after the operation.

2) Gastrointestinal disturbances such as diarrhoe, nausia, anorexia and prostration were observed at 15-20 days after the operation. Thereafter these symptoms were restored gradually and appetite was found to be getting better and ac-cumulation of fatty adipose was found rather than before.

3) Decreasing of eosinophilic leucocytes and NA in urine, increase of 17 OHCS in urine and changes of responses to Adrenaline, Insulin and ACTH in the animals suggested that the functional dis-order of thalamuspituitary-adrenal axis.

4) Significant fatty degeneration in the liver and remarkable increasing of connective tissue in the spleen and ruined findings of the greater part of thalamus and hypothalamus in reserved side, and cystic formation or adhesion with dura mater in operation side were observed as hestological find-ings.

5) In the long living dogs after hemispherectomy, somewhat abnormal conditions were obsereved in the thalamus-pituitary-adrenal axis and slight changes in other organs, but the adaptation sys-tem, pituitary-adrenal axis is not seen to be in-fluenced by hemispherectomy. These compensa-tion ability for the adaptation system depends on function of diencephalon in opposite side.