長期生存を認める大脳半球原発Neuroblastomaの1例

A Case of Primary Cerebral Neuroblastoma Surviving for Eight Years

I．はじめに

　大脳半球原発neuroblastomaは10歳以下の小児に好発し，発生頻度は，原発性脳腫瘍の0.2％とされ，その予後は不良で，大多数の症例は短期間で再発している^4,6-8）．今回，われわれは10歳時に発症し二期的に手術を行い，放射線療法，化学療法を行わず，8年8カ月を経過した現在，再発を認めていないneuroblastomaの1例を経験したので文献的考察を加え報告する．

We report a case of a patient with primary cerebral neuroblastoma who has survived for 8 years. A 10-year-old boy was admitted to our hospital because of headache and nausea. CT scan on admission revealeda large cystic tumor on the right frontal lobe. Subtotal tumor resection was carried out. A second operationwas performed for the residual tumors which were removed meticulousy with confirmation of the absenceof tumor cells on each frozen section. After tumor removal, YAG laser was applied at each local area. Histological diagnosis disclosed primary cerebral neuroblastoma. Because of postsurgical meningitis andparent's refusal, neither chemotherapy nor radiation therapy was performed. There have been no findingsof the tumor recurrence during the last eight years, and now the patient is enjoying high school life to thefull, without any neurological deficits.

In reviewing the literature, outcomes of neuroblastoma cases are very poor. Our case seems to be one ofthe rare long-survival cases.