呼吸不全の重症度よりみた，安静時および運動負荷時の肺循環障害，組織hypoxiaと酸素効果の検討

Disturbances of pulmonary hemodynamics, tissue hypoxia and the effects of oxygen administration in patients with chronic pulmonary disease

　慢性呼吸不全患者では安静時すでに，または労作時に肺循環障害や組織hypoxiaを来たし，酸素療法の治療対象となる。肺循環障害や組織hypoxiaの程度は基礎疾患や呼吸不全の重症度により差があると考えられ，また安静時のみではわからない病態が運動負荷を課することにより判明しうる。そこで肺結核後遺症と慢性閉塞性肺疾患を基礎疾患にもつ慢性呼吸不全症例について，各各を安静時PaO₂のレベルよりPaO₂60mmHg以上の群（I群）と60mmHg未満の群（II群）に分け，安静時および運動負荷時の肺循環障害と組織hypoxiaについて検討した。さらに一部の症例については酸素投与によるこれら諸量への影響についても検討を加えた。

We studied the disturbances of pulmonary hemodyna-mics, tissue hypoxia and the effects of oxygen admini-stration at rest and during exercise in patients with chronic respiratory failure based on old pulmonary tuberculosis (n=2) and chronic obstructive pulmonary disease (n=21).

We devided these patients into two groups in view of the degree ol PaO₂ (mmHg), one was over 60mmHg (Group-I, n=29) and the other was below 60mmHg (Group-II, n=17).

The results were following ; (1) Group-I showed mild disturbances of pulmonary hemodynamics and tissue hypoxia at rest, but, showed apparent disorders during exercise.(2) Group-II showed disorders at rest. (3) The disturbances of pulmonary hemodynamics improved partially by oxygen administration both in Group-I and Group-II during exercise. And tissue hypoxia (PVO₂) improved by oxygen adminitration both at rest and during exercise.

We concluded that some aids including oxygen administration are of necessity for not only Group-II but also Group-I.