Cardiac function in stable left ventricular hypertrophy induced by pressure and volume overloading Tomio Abe 1 1Department of Thorac. & Cardiovas. Surgery, Sapporo Medical College pp.285-292
Published Date 1980/3/15
DOI https://doi.org/10.11477/mf.1404203536
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We have compared cardiac function and myo-cardial metabolism in stable canine left ven-tricular hypertrophy (LVH), which was produced by pressure overloading (aortic banding) and volume overloading (bilateral femoral A-V fistula), with those of the normal heart (N) at rest and with exercise until exhausion.

Indices of LV function (cardiac output, stroke volume, minute work, stroke work, peak LV dp/ dt-to-isovolumic pressure) were in the normal or above normal range at rest in LVH. With exercise, these indices increased in N and pressure-overloaded hearts similarly, but the increments in function in volume-overloaded hearts were not significantly elevated. Cardiac O2 extraction was maximal at rest in LVH increased by either pressure or volume overloading and did not increase with exercise as in N, suggesting that the hypertrophied ventricle meets the increased O2 demands of exercise only by increasing coronary blood flow.

Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.


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