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Effects of nifedipine on pulmonary circulation in patients with chronic cor pulmonale Kaztishiae Sakaguchi 1 , Yoshihiko Araki 1 , Yasunori Obata 1 , Masateru Sawada 1 1The Third Department of Internal Medicine, Osaka Prefectural Habikino Hospital pp.759-763
Published Date 1987/7/15
DOI https://doi.org/10.11477/mf.1404205090
  • Abstract
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The effects of sublingual nifedipine (10 mg) on right ventricular performance were studied in 13 patients with pulmonary hypertension secondary to chronic lung disease.

Total pulmonary vascular resistance (TPVR) dec-reased from 8.3±7.0 to 6.6±5.2 unit (mmHg×min/l) after nifedipine administration (p <0. 05). Cardiac index (CI) increased 3.7±1.2 to 4.5±1.6 l/min/m2 (p<0.01). There was no significant fall in pulmo-nary arterial mean pressure (PAMP), exacerbations of pulmonary hypertension were observed in two patients. Mean arterial pressure decreased from 94.6±11.0 to 86.2±823 mmHg (p<0.01), in associa-tion with a reflex increase in heart rate from 86.5± 19.2 to 95.7±23.3 beats/min (p <0.01). There was no significant fall in PaO2, and PvO2,while O2-trans-port increased significantly (p<0.01).

In conclusion, nifesipine induced a significant inc-rease in CI and O2-transport, however no change in PAMP. Nifedipine has not always been success-ful and possible harmful side effects have been demonstrated. The administration of active vasodi-lator agents in patients with pulmonary hypertension secondary to chronic lung disease clearly requires careful monitoring of intravascular pressure and right ventricular performance in order to detect unsuspected untoward effects.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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