22q11.2欠失症候群を背景とした慢性活動性Epstein-Barrウイルス感染症に両肺の多発結節を認めた1例

A case of chronic active Epstein-Barr virus infection with multiple pulmonary nodules associated with 22q11.2 deletion syndrome

慢性活動性Epstein-Barrウイルス（EBV）感染症（chronic active Epstein-Barr virus infection：CAEBV）は長期の伝染性単核症様症状と末梢血EBV-DNA高値を特徴とする疾患で，間質性肺炎や冠動脈瘤などの合併が報告されている。しかし，CAEBVに多発肺結節を呈した症例の報告は少ない。今回我々は，22q11.2欠失症候群を背景としてCAEBVを発症し，CTにて両肺に多発結節を認めた1例を経験したため，文献的考察を加えて報告する。

Chronic active Epstein-Barr virus infection（CAEBV）is a disease characterized by chronic mononucleosis-like symptoms and elevated serum EBV-DNA copies. While various complication is reported such as interstitial pneumonia and coronary aneurysms, multiple pulmonary nodules are relatively rare findings. We report a case of an 11-year-old girl with 22q11.2 deletion syndrome who developed CAEBV and presented multiple pulmonary nodules. Although the pulmonary nodules shrank with treatment, multi-organ failure progressed slowly, and she died 4 months after admission. Radiologists must be aware that CAEBV can cause diverse complications.