Macrolide-resistant Mycoplasma pneumoniae Mitsuo Narita 1 1Department of Pediatrics, Sapporo Tokushukai Hospital Keyword: 薬剤耐性機構 , 23SリボソームRNAドメインV , 点突然変異 , プラスミド , オペロン pp.868-872
Published Date 2012/8/15
DOI https://doi.org/10.11477/mf.1542103098
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Epidemics of Mycoplasma pneumoniae pneumonia had been seen at 4-year intervals before 1990 during which time bacteriostatic antibiotics were used. Since 1991, when the bactericidal antibiotic clarithromycin was introduced into clinical practice, large epidemics gradually subsided. However, since 2000, when the first clinical strain of drug-resistant Mycoplasma pneumoniae was isolated, annual occurrence of Mycoplasma pneumoniae pneumonia has been increasing up to the present time. These epidemiologic observations strongly suggest that a certain causative event that increased resistance must have occurred in 2000, which subsequently has become widespread year by year. On this point, it is of note that azithromycin was introduced into clinical practice in 2000.

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