筋萎縮性側索硬化症における症候の左右差

Asymmetric affection in amyotrophic lateral sclerosis

　変性性神経疾患の症候は一般に対称性であるが，運動ニューロン疾患とパーキンソン病はその点で顕著な例外である。本稿の目的は前者に関する資料をまとめ，考察することである。

Abstract

Clinical manifestations of amyotrophic lateral sclerosis (ALS) and spinal progressive muscular atrophies (SPMA) are very often asymmetric, particularly in their early stages. In 326 cases of motor neuron diseases showing no initial bulbar signs, only the upper extremities were affected initially in 152; of which 63 on the right only, 45 on the left only and 44 on the both. The lower extremities were affected in 104; 35 on the right, 15 on the left and 54 on the both. In 19.8% of 369 cases of ALS as well as in 13.7% in 102 cases of SPMA, clinical picture was still asymmetric at about a half year before death.