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Japanese

Morphological studies on the methylnitrosourea-induced tumors of the nervous system, with special reference to nerve tumors Masaru TAMURA 1 1Department of Neurosurgery, School of Medicine, Gunma university pp.148-162
Published Date 1975/2/10
DOI https://doi.org/10.11477/mf.1431903699
  • Abstract
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A total of 103 Donryu rats at the age of 3 or 4 weeks, weighing 30 to 40 g, were used and divided into 3 groups. The animals in Group A were weekly given intravenously 10 mg/kg of methylnitrosourea (MNU) dissolved in saline, and animals in Group B 5 mg/kg of MNU. In Group C, control rats were weekly treated intravenously with saline.

Fifty-four rats out of 79 given MNU, with duration of survival ranging from 137 to 365 days, were found with single or multiple tumor development in the nervous systems. The number of the tumors induced amounted to 73.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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