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Neuronal cell death via TPK I-In vitro model of Alzheimer disease Koichi ISHIGURO 1 , Minako HOSHI 1 , Akihiko TAKASHIMA 1 1Mitsubishi Kasei Institute of Life Sciences Keyword: アミロイドβ , TPK I/GSK-3β , 神経細胞死 pp.105-114
Published Date 1997/2/10
DOI https://doi.org/10.11477/mf.1431901458
  • Abstract
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Histopathological features of Alzheimer's disease (AD) include extracellular deposits of amyloid β (Aβ) fibril in the cores of senile plaques, intracellular neurofibrillary tangles (NFT) which are composed of paired helical filaments (PHF), and neuronal cell loss. The main component of PHF is highly phosphorylated tau protein. We identified a protein kinase converting normal tau into PHF-like state. The kinase is tau protein kinase (TPK) I/glycogen synthase kinase (GSK)-3β. Using neuronal cell culture system as AD model, it has beeen realized that TPK I/GSK-3β plays a central role in AD pathology.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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