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Chromatin modification in pathogenesis of polyglutamine diseases Shuichi IGARASHI 1 1Department of Molecular Neuroscience, Center for Bioresouce-based Researches, Resource Branch for Brain Disease Research, Brain Research Institute, Niigata University Keyword: polyglutamine disease , histone acetyltransferase , HDAC , histone modification pp.711-717
Published Date 2002/10/10
DOI https://doi.org/10.11477/mf.1431901394
  • Abstract
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Transcriptional dysregulation in neurons could be one of the major mechanisms by which mutant expanded polyglutamine causes neuronal dysfunction and cell death. Transcription factors and cofactors such as CBP and TAFII130 are incorporated into aggregates containing expanded polyglutamine following the accumulation of expanded polyglutamine stretches. An inappropriate interaction between expanded polyglutamine and histone acetyltransferase has been reported to cause abnormal histone acetylation resulting in abnormal transcriptional regulation.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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