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Reaction and function of microglia in the pathological state. Kazuyuki NAKAJIMA 1 , Akinori SHIMADA 1 , Shinichi KOHSAKA 1 1Department of Neurochemistry, National Institute of Neuroscience pp.665-676
Published Date 1993/8/10
DOI https://doi.org/10.11477/mf.1431900358
  • Abstract
  • Look Inside

Microglia, a type of glial cells in the central nervous system (CNS), are distributed as ramified microglia with a certain regular spaces in normal adult brain parenchyma, and is generally believed to be transformed from ameboid microglia (brain macrophages). But, their ontogenic origin is now controversial; there are two lines, monocyte-methodermal and neuroectodermal origin.

Once brain is injured or taken brain disease, microglia are activated, proliferated and accumulated in the injured sites. These reactive microglia are thought to be involved in defense against the infec-tion, phagocytic scavenge of dead cells, antigen presentation, gliosis and tissue repair. However, CNS injures and most of brain diseases are usually accompanied by disruption of the vasculature and a following invasion of blood-derived monocytes and macrophages into the parenchyma. Since there is no microglia specific markers which can distinguish from other peripheral macrophages, it is difficult to observe only microglial reactions or roles in injured sites.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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