Establishment and Maintenance of Adult Neural Stem Cells Naoya Yuizumi 1 , Yujin Harada 1 1Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo Keyword: 成体神経幹細胞 , 神経新生 , 幹細胞ニッチ , 細胞分裂 , 細胞周期抑制因子 , adult neural stem cell , neurogenesis , stem cell niche , cell division , CDK inhibitor pp.1027-1034
Published Date 2017/9/1
DOI https://doi.org/10.11477/mf.1416200862
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Neural stem cells (NSCs) in the adult mammalian brain produce new neurons throughout life. Defects in adult neurogenesis can influence neurodegenerative and psychiatric disorders. Hence, understanding long-term maintenance of adult NSCs is crucial. Cell-intrinsic and -extrinsic factors contribute to long-term maintenance of adult NSCs, and we have previously reported that NSCs produce their own niches that send a feedback signal for their own maintenance. In addition, we have identified a slowly dividing subpopulation of embryonic neural progenitor cells that is set aside during development, and later becomes a substantial fraction of NSCs in the adult subventricular zone. Here, we review the mechanisms of long-term maintenance and embryonic origin of adult NSCs. We also discuss current topics on adult NSCs and future perspectives in this field of study.

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