Positron Emission Tomography Imaging of Microglia in Diagnosis of Dementia Miho Shukuri 1 , Hirotaka Onoe 2,3 1Division of Pharmaceutical Chemistry, Showa Pharmaceutical University 2Division of Neurobiology and Physiology, Graduate School of Medicine Kyoto University 3Bio-Function Imaging Team, RIKEN Center for Life Science Technologies Keyword: 神経炎症 , シクロオキシゲナーゼ , 非ステロイド性抗炎症薬 , ポジトロンエミッション断層撮像法 , トランスロケーター蛋白(TSPO) , neuroinflammation , cyclooxygenase(COX) , nonsteroidal anti-inflammatory drugs(NSAIDs) , positron emission tomography(PET) , translocator protein(TSPO) pp.1017-1026
Published Date 2017/9/1
DOI https://doi.org/10.11477/mf.1416200861
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Neuroinflammation which involves microglial activation is believed to be closely associated with the progression of neurodegeneration in Alzheimer's disease. The activation of microglia is receiving rising attention as a diagnostic and therapeutic target; however, it is important to distinguish its state and phenotype of the microglia. Positron emission tomography (PET) is a non-invasive method that can help visualize the changes of molecules associated with microglial activation in neurological disease under in vivo conditions. In this review, recent PET preclinical and clinical studies, and new molecular targets for the imaging of microglia are described.

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