当科で経験した孤立性線維性腫瘍3例の検討

Three cases of solitary fibrous tumors in the head and neck region

はじめに

　孤立性線維性腫瘍（solitary fibrous tumor：SFT）は，1931年にKlempererら^1）により初めて報告された間葉系細胞由来の腫瘍で，好発年齢は中高年であり，明らかな性差はないとされる^2）。主な好発部位は胸膜だが，全身の軟部組織に発生が報告されている。一方，頭頸部領域における発生は比較的稀とされる。SFTのなかには時に周囲組織への浸潤や遠隔転移をきたす例もあり，注意が必要な腫瘍の1つである。

　今回，当科で経験した3例について文献的考察を加え報告する。

　Solitary fibrous tumors（SFTs）are mesenchymal tumors that are relatively rare in the head and neck regions. Herein, we report three cases of SFTs in the salivary glands. In two cases, the tumor was located in the submandibular region, and in one case it was located under the mucous layer on the cheek. All three tumors were diagnosed as SFTs after removal. Microscopy revealed densely proliferated spindle-shaped cells in all three cases. As a result, CD34 expression was determined using immunohistochemical staining, and only the third case was found to be malignant due to nuclear dysplasia and abnormal mitosis.