ラタノプロスト点眼による眼瞼の色調変化と多毛

Discoloration and hypertrichosis in the eyelids following instillation of latanoprost

　ラタノプロスト点眼薬を1日1回使用した緑内障患者317例のうち，使用開始49日から238日の間に，257例（81.1％）の眼瞼に異常が生じた。異常の内容は，眼瞼の色調変化128例（40.4％）と，眼瞼の多毛244例（77．O％）である。男女間に差はなく，それまでのウノプロストン点眼液の使用の有無には無関係であった。最終判定までの平均使用量は，1眼あたり2.5mlの点眼瓶2.9本であったが，多数例で1眼1本を点眼しただけで眼瞼異常が起こった。点眼を中止するとゆっくり軽快した。以上の症例は，点眼後の拭き取りを特に指示しなかった発売当初の群であり，現在は拭き取りを徹底させて観察している。

Eyelid disorders were detected in 257 of 317 glaucoma patients (81.1%) following topical treatment with latanoprost ophthalmic solution once a day. Discoloration of eyelids was found in 128 cases (40.4%) and hypertrichosis in 244 cases (77.0% ) . The duration of latanoprost instillation ranged from 49 to 238 days. The incidence of eyelid disorders was the same in males and females and was independent of the previous use of unoprostone. The total dosis of latanoprost per eye averaged 2.9 bottles containing 2.5ml. Eyelid changes developed even after instillation of one bottle per eye only in numerous cases. The abnormal findings gradually disappeared following cessation of medication. Above observation was made when the patients were not advised to wipe the eyelid after instillation. Further observation is under way after advising the patients to wipe the eyelid area thoroughly right after instillation.