ラタノプロスト点眼における眼圧の変動

Diurnal fluctuation of intraocular pressure following additional topical latanoprost

　βプロッカー薬を1日2回点眼している緑内障25例50眼にラタノプロストの就寝前1回点眼を追加し，眼圧下降効果を評価した。追加点眼で午前・午後ともに眼圧が有意に低下した。開放隅角緑内障20眼では，追加前には午後に有意な眼圧上昇があったが，追加後には午前・午後間に有意差がなくなり，午後の眼圧上昇が抑制された。正常眼圧緑内障16眼では，午後の眼圧上昇を抑制できなかった。血管新生緑内障6眼では，午後の眼圧上昇が抑制された。βプロッカー薬へのラタノプロスト追加は，終日の安定した眼圧降下に効果があった。

We evaluated the effect of topical latanoprost in 50 glaucoma eyes in 25 patients. Initially, all the patients had been receiving beta-blocker instilled twice daily. Latanoprost was added to be instilled once before sleep. After additional use, the intraocular pressure (IOP) significantly decreased both in the morning and afternoon. In 20 eyes of primary open-angle glaucoma, there had been a significant IOP rise in the afternoon than in the morning. After additional use, this IOP rise in the afternoon was suppresed resulting in no IOP difference between morning and afternoon. Additional use failed to suppress the IOP rise in the afternoon in 16 eyes of normal-tension glaucoma. Additional use suppressed IOP rise in the afternoon in 6 eyes of neovascular glaucoma. Additional use of latanoprost to beta-blocker thus induced lowering of IOP without diurnal fluctuation.