Involvement of the second eye after a long interval in two cases of Leber's hereditary optic neuropathy Astuya Ochiai 1 , Noriko Saito 1 , Youji Kashima 1 , Hiroshi Ishikawa 1 1Dept of Ophthalmol, Nihon Univ Sch of Med pp.1047-1050
Published Date 1998/6/15
DOI https://doi.org/10.11477/mf.1410905915
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A 17-year-old male with positive family history developed typical features of Leber's hereditary optic neuropathy in his right eye. His left eye became affected 17 months later. Another 48-year-old male without family history and with heavy drinking habit developed the disease in his left eye following blunt head trauma. His right eye became affected 16 months later. Both cases showed mutation in the 11778 mitochondrial DNA. These cases illustrate that the second eye may be involved after a long interval in this disease entity.

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