Correlation between the soluble Fas molecule and age in Behçet's disease Junko Suemaru 1 , Ayano Nouchi 1 , Tetsuya Muto 1 , Shouichi Sukegawa 1 , Takako Tachikawa 1 , Hiroshi Ujihara 1 , Goro Inaba 1 , Yoshitaka Miyanaga 1 , Hidehiko Karai 2 1Dept of Ophthalmol, Tokyo Women's Med Coll Daini Hosp 2Kanagawa Prefecture Rehabilitation Centre Inst pp.765-768
Published Date 1998/5/15
DOI https://doi.org/10.11477/mf.1410905852
  • Abstract
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We quantified the soluble Fas protein (sFas) in the sera of 20 patients with Behçet's disease using sandwich ELISA. The sFas level was significantly elevated in 7 patients in the active stage and in 13 in the inactive stage. There was no significant difference between the two groups. The sFas level was positively correlated with age in patients in the inactive stage and in 9 healthy controls. It was not correlated with age in patients in the active stage. There was an increase in sensitivity of T cells to Fas antigen in the peripheral blood of 12 patients after activation by concanavallin A. The Fas sensitivity of T cells was positively correlated with improvement of acute ocular inflammation. Above findings seemed to suggest that fluctuation of sFas system induces disappearance of its correlation with age. Activated T cells also seemed to induce regression of inflammation.

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