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Dynamics of intercellular adhesion molecules and interleukin-2 receptor in Behçet and Vogt-Koyanagi-Harada diseases Toshihiro Matsumoto 1 , Eiichi Uchio 1 , Misaki Ishioka 1 , Shun-ichi Tanaka 2 , Shigeaki Ohno 1 1Dept of Ophthalmol, Yokohama City Univ Sch of Med 2Dept of Internal Med, Yokohama City Univ Sch of Med pp.287-291
Published Date 1996/3/15
DOI https://doi.org/10.11477/mf.1410904755
  • Abstract
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We measured the serum levels of soluble form of ICAM-1, CD4, CD8 and interleukin-2 receptor (IL-2R) in 20 patients with active Behçet disease and 20 with Vogt-Koyanagi-Harada disease (VKH). The level of ICAM-1 was significantly higher in both diseases during the active or acute stage as compared with 20 normal persons. In Behçet disease, the level of ICAM-1 was significantly elevated in convalescent stage than in acute stage. The levels of CD4 and I1-2R were significantly higher in Behçet disease in both stages and in VKH in the acute stage than in controls. In both diseases, IL-2R levels were significantly less during the convalescent stage than in acute stage. In both diseases, the levels of CD8 were significantly increased than in controls. The CD4 and IL-2R levels were positively correlated in both disease during the acute stage. The findings show that these soluble markers may serve as potentially useful parameters in monitoring the activity of both diseases.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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