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日本人の眼サルコイドーシス患者66例についてHLAを検索した。男性30例,女性36例であり,138例の健常者を対照とした。患者群全体および全身的因子について,HLAに特定の傾向はなかった。網膜血管周囲炎のある患者群にHLA-DRI4が多い傾向があり,炎症が前眼部に限局している群でHLA—Allが有意に高頻度であり,眼内の炎症発現の部位へのHLAの関与が推定された。男性患者群にHLA—DR2が有意に高頻度であり,女性患者群にはHLA-DR53が多い傾向があった。眼サルコイドーシスへのHLAの関与に性差があることが推定された。
We evaluated 66 Japanese patients with ocular sarcoidosis regarding human leukocyte antigen, HLA. The series comprised 30 males and 36 females. HLA tests in 138 healthy persons served as control. No definite trends were observed in HLA factors in general and in relation to systemic features. The frequency of HLA-DR14 in patients with periphlebitis was marginally increased and HLA-All in patients with anterior segment involvement only was significantly increased, suggesting that HLA may influence the site of intraocular inflammation. Males showed a significantly high incidence of HLA-DR2. Females showed high incidence of HLA-DR53, which was not significant. The findings suggested different patterns of HLA between males and females.
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