Epithelial downgrowth after penetrating keratoplasty for corneal perforation Tomo Kimura 1 , Hiroto Obata 1,2 , Kazunori Miyata 1 , Shiroaki Shirato 1 , Tadahiko Tsuru 3 , Mitsuru Sawa 4 1Dept of Ophthalmol, Univ of Tokyo Sch of Med 2Dept of Pathol, Univ of Tokyo Sch of Med 3Section of Corneal Transplantation, Univ of Tokyo Hosp 4Dept of Ophthalmol, Nihon Univ Sch of Med pp.1955-1959
Published Date 1993/12/15
DOI https://doi.org/10.11477/mf.1410901985
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A 33-year-old male underwent penetrating ker-atoplasty for corneal perforation secondary to herpetic keratitis. Retrocorneal membrane suggest-ing epithalial downgrowth was observed 5 daysafter surgery. The corneal graft remained clear and the intraocular pressure remained normal until the intraocular pressure rose to 38mmHg 10 years later. The condition was controlled by trabeculectomy with postoperative subconjunctival 5-fluorouracil. The surgically obtained specimen showed squamous cell proliferations on the iris surface. These cells stained positive for monoclonal antibody to 64kD cornea-specific keratin. The findings suggest that these cells were derived from corneal epithelium.

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