モキシフロキサシン添加灌流液を用いた白内障手術の安全性

Safety of irrigating solution containing moxifloxacin in cataract surgery

要約　目的：濃度45μg/mlモキシフロキサシン（MFLX）を灌流液に用いた白内障手術の安全性の検討。対象と方法：白内障手術を施行された149眼について，MFLX添加灌流液を用いた77眼の角膜内皮細胞密度，中心角膜厚および中心窩網膜厚への影響を術後1か月の時点でコントロール群72眼と比較した。結果：コントロール群，MFLX群の角膜内皮細胞密度はそれぞれ術前では，2,469±367cells/mm²，2,481±321cells/mm²，術後1か月では2,215±469cells/mm²，2,116±491cells/mm²で，両群に有意差はなかった。中心角膜厚，中心窩網膜厚でも，同様に有意差はなかった。結論：本法による角膜，網膜に対する有害な作用を認めず，安全性が確認された。

Abstract.　Purpose：To report the safety of irrigating solution containing moxifloxacin（MFLX）in cataract surgery. Cases and Method：This prospective study was made on 149 eyes of 111 cases who received cataract surgery with intraocular lens implantation in the past 12 months. The series comprised 53 male and 96 female eyes. The age averaged 78 years. Irrigating solution containing 45μg/ml of MFLX was used during surgery. Another series of 72 eyes served as control that received surgery with balanced salt solution for irrigation. Cases were evaluated regarding corneal thickness, endothelial cell population, and foveal thickness before and one month after surgery. Results：Before surgery, corneal endothelial cell density averaged 2481±321 cells/mm² in MFLX group and 2469±367 cells/mm² in controls. There was no significant difference. One month after surgery, it averaged 2116±491 cells/mm² and 2215±469 cells/mm² respectively. There was no significant difference. No significant differences were present between the two groups regarding central corneal thickness or foveal thickness. Conclusion：Use of irrigating solution containing MFLX showed no adverse effect on the cornea or the fovea one month after cataract surgery.