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要約 目的:非結核性抗酸菌の治療薬リファブチンの内服中に発症したぶどう膜炎2症例の報告。症例:いずれも女性で,64歳と81歳である。1例は25年前に多発性骨髄腫があり,5年前に非結核性抗酸菌による肺炎が発症し,肺アスペルギルス症が続発し,2か月前からリファブチンなどの投与を受けていた。他の1例は60年前に結核に罹患した。4年前にMycobacteriumによる呼吸器感染があり,3か月前からの再発に対しリファブチンなどで加療中であった。所見:両症例とも,前房蓄膿を伴うぶどう膜炎が右眼にあった。リファブチンの投与を中止し,1例には硝子体手術を行った。それぞれ2日後と10日後に眼内炎は鎮静化した。結論:これら2症例での汎ぶどう膜炎はリファブチン内服が原因であったと推定され,投薬中止で治癒が得られた。
Abstract. Purpose:To report two cases who developed panuveitis following systemic treatment with rifabutin. Cases:Both were females aged 64 and 81 years. One had had multiple myeloma 25 years before,had pneumonia due to nontuberculous mycobacteria 5 years before,and been receiving rifabutin since 2 months before. The other had had pulmonary tuberculosis at the age of 20 years,had pneumonitis due to Mycobacterium,and been receiving rifabutin since 3 months before. Findings:Both cases had hypopyon uveitis in the right eye. Rifabutin was immediately discontinued. One case received vitrectomy. Intraocular inflammation subsided 2 and 10 days respectively after withdrawal. Conclusion:Systemic rifabutin appears to have been the cause for uveitis in the present cases. Discontinuation of rifabutin was followed by early cure of uveitis.
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