緑内障眼における網膜神経線維層厚測定値と視野障害との相関

Correlation between visual field defect and retinal nerve fiber layer thickness in glaucoma

要約　目的：緑内障における網膜神経線維層厚と視野障害の相関の報告。対象と方法：広義の原発開放隅角緑内障62例120眼を対象とした。男性62眼，女性58眼であり，年齢は平均50.2±18.1歳であった。網膜神経線維層厚はOCT3000で測定し，視野はHumphrey自動視野計のmean deviation（MD）とpattern standard deviation（PSD）で評価した。結果：網膜神経線維層厚は，MD値（r＝0.717，p＝0.000）およびPSD値（r＝－0.566，p＝0.000）と有意の相関があった。MD値による病期分類では，網膜神経線維層厚とMD値間の有意の相関は初期群と後期群のみにあり，中期群ではなかった。結論：緑内障眼での網膜神経線維層厚と視野障害との間には有意の相関がある。この相関は中期の緑内障では乏しいので，注意が必要である。

Abstract.　Purpose：To report the correlation between visual field defect and retinal nerve fiber layer thickness（RNFLT）in glaucoma. Cases：This study was made on 120 eyes of 62 patients who were diagnosed with primary open-angle glaucoma in its broader sense. The series comprised 62 male and 58 female eyes. The age averaged 50.2±18.1 years. RNFLT was measured by optical coherence tomography（OCT3000）. Visual field was evaluated by mean deviation（MD）and pattern standard deviation（PSD）of Humphrey automated perimeter. Results：RNFLT showed a significant correlation with MD（r＝0.717, p＝0.000）and PSD（r＝－0.566, p＝0.000）. When glaucoma was classified into 3 groups according to MD value, correlation between RNFLT and MD was present only in early and advanced stages and was absent in medium stage. Conclusion：RNFLT in glaucoma is significantly correlated with visual field defect. This correlation may be less apparent in moderately advanced glaucoma.