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Effect of levobunolol switched from timolol gel-forming solution Kenji Inoue 1 , Masato Wakakura 1 , Jiro Inouye 1 , Goji Tomita 2 1Inouye Eye Hosp 2Dept of Ophthalmol,Univ of Tokyo Grad Sch of Med pp.263-267
Published Date 2006/3/15
DOI https://doi.org/10.11477/mf.1410100374
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Purpose:To evaluate ocular hypotensive effect and comfort before and after switching 0.5% timolol gel-forming solution to levobunolol once daily. Method:This prospective study involved 35 eyes of 35 glaucoma patients. The series comprised 13 males and 22 females and included primary open-angle glaucoma 24 eyes,normal-tension glaucoma 7 eyes,primary angle closed glaucoma 3 eyes and ocular hypertension one eye. Intraocular pressure(IOP)was measured once a month for 3 months. Results:IOP before switching averaged 17.1±1.9 mmHg. It decreased significantly 2 months after switching. There was no difference from baseline value 1 and 3 months after switching. Patients complained of stickiness and blurred vision before switching. Levobunolol was preferred to timolol by 18 patients(51%). Conclusion:There was not difference in IOP before and after switching timolol to levobunolol up to 3 months. Ocular comfort was better while using levobunolol than timolol gel-forming solution.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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