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Hypotensive effect of switching from brinzolamide twice daily to dorzolamide or brinzolamide thrice daily Kenji Inoue 1 , Minako Shiokawa 1 , Masato Wakakura 1 , Jiro Inouye 1 , Goji Tomita 2 1Inouye Eye Hosp 22nd Dept of Ophthalmol,Toho Univ Sch of Med pp.63-67
Published Date 2009/1/15
DOI https://doi.org/10.11477/mf.1410102584
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Abstract. Purpose:To compare the effect of topical brinzolamide and dorzolamide thrice daily. Cases and Method:This study was made on 28 eyes of 28 patients who had been receiving latanoprost and brinzolamide twice daily for primary open-angle glaucoma. In 15 patients,brinzolamide was increased from twice to thrice daily. In 13 patients,brinzolamide was switched to 1% dorzolamide thrice daily. Latanoprost was continued in both groups. Intraocular pressure(IOP)was monitored for 3 months after switching. Results:Three months after switching,IOP in 15 eyes receiving brinzolamide decreased by an average of 1.2 mmHg(p<0.0001). In 13 eyes receiving dorzolamide,IOP decreased by an average of 1.2 mmHg(p<0.01). Conclusion:Instillation of brinzolamide thrice daily or dorzolamide thrice daily has greater hypotensive effect for primary open-angle glaucoma than brinzolamide twice daily.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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