Japanese

Sustained Improvement of Pulmonary Hemodynamics by Beraprostsodium Therapy in a Patient with Primary Pulmonary Hypertension Hajime Matutani 1 , Ken Hirose 1 , Hidehiko Suzuki 1 , Takashi Nakaji 1 , Yasuhito Horie 1 , Hiroshi Harasawa 1 , Takaaki Nakamoto 1 , Masahiko Iizuka 1 1First Department of Internal Medicine, Dokkyo Univer-sity School of Medicine Keyword: 原発性肺高血圧症 , 心不全 , prostaglandin I2 , PPH , right ventricular failure pp.877-881
Published Date 1996/8/15
DOI https://doi.org/10.11477/mf.1404900017
  • Abstract
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The patient is a 50-year-old male. In these 2.6 years, he has been under oral prostaglandin E1 therapy and home oxygen therapy at our outpatient clinic with a diagnosis of primary pulmonary hypertension (PPH). He was admitted to our hospital because of the aggra-vation of pulmonary hemodynamics. Oral administra-tion of beraprostsodium (BPS), a stable prostaglandin I2 derivative, was given at the initial dose of 60μg/dayand final increase dose of 180μg/day. Both the arterial pressure and pulmonary arterialar resistance were de-creased. This improvement is considered to be due to its vasodilative, antiplatelet activity, antiplatelet and antithrombotic actions of BPS. It was suggested that BPS effectively suppress the progress of the PPH.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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