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Pathological Diagnostic Criteria and Issues with Serrated Lesions of the Colorectum Based on WHO 2019 Criteria Yoshihito Tanaka 1 , Makoto Eizuka 1 , Tamotsu Sugai 1 1Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Iwate, Japan Keyword: 大腸鋸歯状病変 , serrated pathway , 病理診断基準 , WHO分類 , SSL pp.1563-1571
Published Date 2020/12/25
DOI https://doi.org/10.11477/mf.1403202202
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 In recent years, the "serrated pathway" concept, wherein serrated lesions of the colorectum are considered as precursor lesions, has been proposed as a new carcinogenic pathway for colorectal cancer and is garnering international attention. However, because serrated lesions of the colorectum are histopathologically and molecularly diverse, sufficient pathological diagnostic criteria have not yet been established. In 2019, WHO(the World Health Organization)classification for gastrointestinal tumors was revised for the first time in nine years, which included the addition of classification and pathological diagnostic criteria for serrated lesions of the colorectum. To establish the criteria for pathological diagnosis of serrated lesions of the colorectum, it is important to understand the lesion's nature and to clarify the histomorphological features that represent the lesion's nature. Hence, there is a need for performing multifaceted evaluations, including molecular analyses, immunohistochemistry, and investigation of clinicopathological features.


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