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Multiple Colonic Carcinoma Suggested to Have Developed from a Colonic Serrated Lesion, Report of a Case Shin Hasegawa 1,2 , Osamu Tsuruta 1,2 , Hiroshi Kawano 1,2 , Keiko Arita 1,2 , Yasuhiko Maeyama 1,2 , Tetsuhiro Noda 1,2 , Shuichiro Nagata 1,2 , Keiichi Mitsuyama 1,2 , Michio Sata 1,2 1Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan 2Department of Endoscopy, Kurume University School of Medicine, Kurume, Japan Keyword: 大腸鋸歯状病変 , 大腸癌 , serrated pathway , 粘液形質 pp.483-491
Published Date 2011/4/25
DOI https://doi.org/10.11477/mf.1403102189

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 An 80-year-old man was referred to our hospital due to multiple protuberance lesions detected by colonoscopy on further examination for fecal occult blood positivity.(A)IIa+IIc-like,(B)Is+IIa-like, and(C)Is-like lesions were found in the transverse colon. As lesions A and B were determined as carcinoma invaded into the deep submucosa(SM), and C was diagnosed as a colonic serrated lesion, transverse colectomy was performed. The histopathological findings were as follows :(A)HP(hyperplastic polyp)and SM massive, which had invaded into the mucosa and had carcinoma with mucus accumulation,(B)SM massive carcinoma with SSA/P(sessile serrated adenoma/polyp), and(C)SSA/P. Both the serrated lesion and carcinoma showed enterocolonic type mucus phenotype at the site of mucin core protein expression, which suggested that the colonic carcinoma developed from the colonic serrated lesion.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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