Stomach and Intestine(Tokyo) Volume 50, Issue 13 (December 2015)

Molecular Features of Colorectal Serrated Lesions Eiichiro Yamamoto 1,2 , Hiro-o Yamano 3 , Yoshihito Tanaka 3 , Hironori Aoki 2 , Taku Harada 4 , Tomoaki Kimura 5 , Tamotsu Sugai 6 , Hiromu Suzuki 2 1Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan 2Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan 3Department of Gastroenterology, Akita Red Cross Hospital, Akita, Japan 4Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan 5Sakoda Hospital, Miyazaki, Japan 6Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine, Morioka, Japan Keyword: 大腸鋸歯状病変 , SSA/P , TSA , DNAメチル化 , MSI pp.1649-1656
Published Date 2015/12/25
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 Serrated lesions include HP(hyperplastic polyp), TSA(traditional serrated adenoma), and SSA/P(sessile serrated adenoma/polyp). However, in this manuscript, some serrated lesions did not satisfy the criteria of these three categories and were defined as intermediate type. SSA/Ps are known to be closely associated with BRAF mutation and the CIMP(CpG island methylator phenotype); this suggests that SSA/Ps are precursors of CRCs(colorectal cancers), with MSI(microsatellite instability). Type II-O(Type II open-pit pattern)was specific to SSA/Ps with BRAF mutation and CIMP. However, molecular and clinical features of TSAs and intermediate type SSA/Ps remain unclear.

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50巻13号 (2015年12月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院