雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Recent Advances in Pathological Diagnosis and Molecular Features of Serrated Lesions Tamotsu Sugai 1 , Yoshihito Tanaka 1 , Noriyuki Uesugi 1 1Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Iwate, Japan Keyword: 鋸歯状病変 , SSL , TSA , SSLD , SuSA pp.1319-1326
Published Date 2022/9/25
DOI https://doi.org/10.11477/mf.1403203007
  • Abstract
  • Look Inside
  • Reference

 Serrated lesions are broadly classified into HP(hyperplastic polyps), TSA(traditional serrated adenomas), SSL(sessile serrated lesions), and SSLD(SSL with dysplasia). Furthermore, HP is divided into microvesicular and goblet cell-rich variants. Whereas the former is distinguished by BRAF mutation, the latter is closely related to KRAS mutation. The histopathological picture of TSA has not been considered problematic, but further studies are needed on borderline cases and the initial picture of TSA. Although the criteria of histological diagnosis of SSA/P(sessile serrated adenoma/polyp)were widely used based on the diagnostic criteria of the Japanese Society for Research on Colorectal Cancer, the nomenclature was changed to SSL in the 2019 revision of the WHO classification. It should be noted that previously diagnosed SSA/P in Japan may not be the same as the SSL diagnosed using WHO criteria. However, no specific detailed histological features of SSLD have been identified. Based on Japanese criteria, SSLD can be classified into two subtypes:adenomatous and carcinomatous types. The newly described SuSA(superficial serrated adenoma)by Hashimoto, Sekine et al. may be a lesion that could be added to the traditional classification of serrated lesions. According to their research, the proliferative zone of this disease is often confined to the central portion of the crypts and KRAS mutation is often found in this disease. Furthermore, the PTPRK/RSPO3 adhesion gene characterizes the disease, with an incidence of approximately 90%. However, the systematic status of SuSA in colorectal tumor classification remains unknown. Although the concept of serrated lesions is becoming clearer, new disease concepts are being proposed. Further study will be required.


Copyright © 2022, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有