Clinical and Pathological Characteristics of Helicobacter pylori-uninfected Signet-ring Cell Cancer of the Stomach ; an Analysis of Case Series Daisuke Yoshimura 1 , Rie Yoshimura 2 , Seiya Kato 3 , Yusuke Kitagawa 1 , Kayoko Nakano 1 , Nobuyoshi Takizawa 1 , Tomohito Chaen 1 , Kaoru Ichida 1 , Sota Umetani 1 , Toshiaki Ochiai 1 , Eikichi Ihara 4 , Yoshihiro Ogawa 4 1Division of Gastroenterology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan 2Medical Checkup Center Wellness, Fukuoka, Japan 3Division of Pathology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan 4Medicine and Bioregulatory Science, Kyushu University, Fukuoka, Japan Keyword: Helicobacter pylori未感染胃癌 , 印環細胞癌 , 低分化腺癌 , 喫煙歴 pp.1051-1060
Published Date 2020/7/25
DOI https://doi.org/10.11477/mf.1403202094
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 We examined all cases at our institute of gastric signet-ring cell carcinoma, which is among the characteristic types of gastric carcinoma without H. pylori infection. Between April 2007 and December 2019, 28 cases were encountered, 26 of which were mucosal carcinomas with characteristic white flat appearance. All cases were observed in the transition zone of the gastric body and the antrum, corresponding to the boundary between the fundic gland and pyloric gland. One typical histopathological finding shows a densely present, mucin-rich signet-ring cell carcinoma in the mucous neck region. In some cases, tumor volume increased in the lamina propria, but invasive carcinoma was rare. We consider future research to discern whether this disease has the potential to progress to invasive carcinoma following H. pylori infection, or if it represents a novel clinical entity as a slow-growing cancer which is independent of H. pylori infection.

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