Characteristics of Gastric Cancer without Helicobacter pylori Infection and its Relation to Background Mucosa Daisuke Yoshimura 1 , Rie Yoshimura 2 , Seiya Kato 3 , Toshiaki Ochiai 1 , Takahiro Mizutani 1 , Tomohito Chaen 1 , Shin-ichiro Fukuda 1 , Kojiro Niho 1 , Risa Iwao 1 , Yusuke Kitagawa 1 , Ryohei Maruoka 1 , Akihiko Nakashima 3 1Division of Gastroenterology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan 2Medical Checkup Center Wellness, Fukuoka, Japan 3Division of Pathology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan Keyword: Helicobacter pylori未感染胃癌 , 食道胃接合部腺癌 , 胃型低異型度腫瘍 , 超高分化型腺癌 , 印環細胞癌 pp.658-670
Published Date 2018/5/24
DOI https://doi.org/10.11477/mf.1403201362
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 We retrospectively investigated patients with gastric cancer without H. pylori(Helicobacter pylori)infection from April 2005 to October 2017. In this study, 50 patients who met the requirement of not being infected by H. pylori in detection diagnosis and endoscopic and histological examinations were enrolled.

 Interestingly, most patients could be classified into three categories. First, in 10 patients, cancer was located at the gastric cardia or gastroesophageal junction. Second, in 16 patients, very well-differentiated adenocarcinomas, all of which were superficial cancers, were located in the fundic gland region. Pathologically, the appearance and immunohistochemical phenotype resembled the foveolar epithelium, fundic gland, pseudopyloric gland, or a composite of them. Third, in 22 patients, signet-ring cell carcinoma was located in the transitional zone of fundic and pyloric glands. Most of them were flat whitish lesions restricted to the mucosa.

 Our study indicated that gastric cancer without H. pylori infection can be classified into at least three distinct categories closely related to the gastric region and background mucosa.

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