Clinicopathological Characteristics of Helicobacter pylori-Uninfected Advanced Gastric Cancer Yuichiro Yoshida 1,2 , Koichi Kurahara 1 , Hiroki Yaita 1 , Yumi Oshiro 3 , Kazuhito Minami 4 , Shohei Uraoka 1 , Koji Ikegami 1 , Takashi Hirata 1 , Hiroshi Wachi 1 , Hitomi Matsuba 1 1Division of Gastroenterology, Matsuyama Red-cross Hospital, Matsuyama, Japan 2Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Pathology, Matsuyama Red-cross Hospital, Matsuyama, Japan 4Department of Surgery, Matsuyama Red-cross Hospital, Matsuyama, Japan Keyword: H. pylori , H. pylori未感染胃癌 , 進行胃癌 , A型胃炎 pp.1061-1076
Published Date 2020/7/25
DOI https://doi.org/10.11477/mf.1403202096
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 To evaluate the characteristics of H. pylori(Helicobacter pylori)-uninfected advanced gastric cancer, we screened 1911 samples of endoscopically or surgically resected gastric cancers for H. pylori-uninfected gastric cancer, excluding those with esophagogastric junctional cancer and remnant gastric cancer. Then, we classified the H. pylori-uninfected gastric cancer cases as either early or advanced cancer. The clinicopathological findings of the advanced cancer cases were retrospectively examined and compared with those of the early cancer cases. We identified 27(1.4%)cases of H. pylori-uninfected gastric cancer, of which six(0.31%)had advanced gastric cancer. The mean age of these six cases was 59.3 years ; they included four males and two females. Furthermore, no complications of type-A gastritis were observed. Of these, four cases showed undifferentiated adenocarcinoma, and the phenotypic expression was that of gastrointestinal mixed type, with a predominance of gastric type or gastric type. Based on macroscopic findings, four cases were classified as type-3 advanced cancer, with submucosal tumor-like features and poor marginal swelling, and three cases were located in the lower third.

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